There are times, though, when this concept doesn't hold up, and as an example of that, I give you exhibit A: Giant-Size Man-Thing. In the 1970s, Marvel published a lot of these types of books - they were called "Giant-Size" because of the page length. There was Giant-Size Fantastic Four, Giant-Size Spider-Man, Giant-Size Avengers, and so on, so there was precedent. But even so, I find it difficult to believe that those in the Marvel bullpen at the time weren't in on the joke, somehow. I mean, come on - it's not like there weren't such things as euphemisms 35 years ago, and this one is one of the more obvious ones.
Perhaps some of the villains in Giant-Size Man-Thing could have been the terrifying Bearded Clam or the dastardly One-Eyed Monster if they wanted to take it a step further. That people bought enough of these books for Marvel to publish more than one issue is a wonder on its own. I have to chuckle, looking at the cover posted above - the woman at the bottom is simply terrified of a giant-size man-thing. I probably would be, too.